Table 2 The heteronemin-regulated gene expressions in cancer

Oral cancer

 OEC-M1 cells

p21

p53, CCND1, PCNA, TGF-

β1, MMP-9 and THBS-1

[11]

 SCC-25 cells

p21 and TGF-β1

p53, CCND1, PCNA, MMP-9 and THBS-1

Breast cancer

 MCF-7 cells

c-Myc, Bcl-2, and p21

ki-67, CCND1, UCP2, EGFR and PD-L1

[10]

 MDA-MD-231 cells

p21

ki-67, CCND1, c-Myc, Bcl-2, EGFR and PD-L1

Non-small cell lung cancer (NSCLC)

 A459 cells

P21, MMP-9

CCND1, CASP-2, p53, and PCNA

[12]

 H1299 cells

–

CCND1, CASP-2, MMP-9, p53, PCNA and p21

Cholangiocarcinoma

 HuccT1 cells and SSP-25 cells

HSPB1, HMOX1, SNAI1, SERPINH1, CREBBP, COL7A1, JUN, CLDN4, NDRG1, EIF2AK3, IL11, BTG1, NOTCH1, FGFR1, VEGFA, COL6A2, CAMK2D, HKDC1, SIRT1, NFAT5, DST, LAMA5, CD44, LTBP4, HSP90B1, SETD2, ZEB2, ADAM17, CDKN1A, ADM2, PLEKHO1, MYC, HIPK1, PLXND1, SERINC5, ADAMTS1, PLAUR, SRPK2, MMP1, ACHE and PFKFB4

ENPEP, IL1A, ITGB2, SNRPF, NRP2, CDC42, CD24, NRP1, PTTG1, RAC2, HPSE, RORB, ITGB6, EPHB4, GPR124, LAMC1, MYLK, TMEM30B, CLIC4, P3H2, SPOCK3, EIF4E2, ENO1, FREM2, CCDC80, CHI3L1, PXDN, CDH2, RBL1, ICAM1, ARHGDIB, RBM47, CALD1, NME1, MMP17, RB1, SDC4, RUNX1T1, CGN, PKM, TACSTD2, SACS, ITGA3, HK2, ALOX5, RBL2, GLYR1, STAT3, SRF, IL13RA2, DEN, COL6A1, CDS1, IL1B, FSTL1, MGAT5, CHD4, SMC3, EPHA1, CEACAM1, HOXB3, VAV3, ILK, C3, SLC2A1, BMP5, DICER1, EPHA2, CAV1, LDHA, KDM1A, IGFBP4, GALNT7, AHNAK, LRG1, VWA2, NFKB1, GTF2I, TP53, DAG1, CMA1, ITGA6, TFDP1, ITGB8, PDGFC, KCNJ8, CDH11, EDN1, PLS1, F3, SMAD3, THBS1, TGFBR2, PTX3, BMP4, VCAN, TGFB2 and LAMA3

[44]

Prostate cancer cells

 DU145 cells and PC-3 cells

–

Bcl-xL, Bcl-2, and cyclin D1

[19]