Fig. 1

DYRK1A promotes malignant progression and especially metastasis in HCC. a and b Immunohistochemical staining of DYRK1A in HCC tissues and normal liver tissues was analysed in the Human Protein Atlas (www.proteinatlas.org). Staining intensity was analysed by using Image Pro-Plus and is presented as integrated optical density per stained area (IOD/area). c The expression of DYRK1A was detected in liver cancer cells and normal liver cells. d and e The levels of DYRK1A in HCC and normal liver tissues are shown. Data obtained from UALCAN (ualcan.path.uab.edu/analysis.html) are shown. Gene: DYRK1A; TCGA dataset: Liver HCC; DYRK1A expression based on d sample type and e nodal metastasis status. The criteria for determining the status of lymph node metastasis in the UALCAN platform were as follows: N0 indicated no regional lymph node metastasis; N1 indicated metastasis to 1–3 axillary lymph nodes. f Data acquired from the Human Cancer Metastasis Database (hcmdb.i-sanger.com/index) are shown. Gene: DYRK1A; Exp ID: EXP00156. g Data acquired from cBioPortal (www.cbioportal.org) are shown. Gene: DYRK1A; Sample type: Liver HCC (TCGA, Firehose Legacy); Survival type: Overall