Post-translational modifications on the retinoblastoma protein

Table 1 E3 ubiquitin ligases that target pRb for ubiquitination

E3 ligase	Adaptor(s)	Functional outputs	References
TRIM71	None	Facilitate breast tumor progression	[35]
RNF123	None	Enhance G1/S phase transition	[36]
NRBE3	None	Accelerate G1/S phase transition and cell proliferation	[37]
MDM2	None	Facilitate cell cycle progression	[24, 39, 41]
	MDMX	Restore pRb functions in cell cycle regulation [44] Enhance G1/S phase transition [45]	[44, 45]
	NIR	Elevate G1/S phase transition and cell proliferation [42]	[42]
SCF^SKP2	EBNA3C	Attenuating pRb-induced G1 arrest	[25]
hUTP14a	None	Upregulate expression of E2F1 regulated genes and enhance proliferation of cancer cells	[38]
Cullin 2	HPV16 E7	Stimulate cell proliferation	[48]
E6AP	NS5B	Stimulate cell proliferation	[50]

ISSN: 1423-0127