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Table 2 Ubiquitination sites of pRb detected by MS

From: Post-translational modifications on the retinoblastoma protein

Cell lines/tissues

Conditions

Ubiquitination sites detected by MS

References

MMTV-Tg (LINK-A) mouse mammary gland tumour

Untreated

K803

[35]

HEK293T cells; MV4–11 cells

Unperturbed (for HEK293T cells); proteasome inhibitor MG132 treatment (for MV4–11 cells)

K810

[51]

Jurkat E6-1 cells

Unperturbed

K63, K65, K265, K279, K289, K319, K329, K359, K420, K640, K791, K810, K814, K844, K847, K870, K896, K900

[52]

U2OS cells

UV treated

K842

[53]

HEK293T cells

UV treated

K97, K823, K842, K846, K856, K879

[54]

Hep2 and Jurkat cells

Treatment with proteasome inhibitors bortezomid and b-AP15

K63, K65, K94, K136, K143, K265, K279, K289, K327, K341, K420, K427, K432, K537, K640, K791, K810, K814, K824, K847, K870, K896, K900 (in Jurkat cells)

K63, K65, K94, K136, K143, K265, K279, K289, K327, K341, K420, K427, K537, K640, K810, K847, K860, K870, K896, K900 (in Hep2 cells)

[55]

HCT116 cells

Combined treatment with bortezomid and cycloheximide

K143

[56]