Post-translational modifications on the retinoblastoma protein

Table 4 pRb methylation and relevant functional outcomes

Site	Methyltransferases/effector proteins	Functional outcomes	References
K810	Set7/9	Suppress E2F1 transcriptional activity and arrest cell cycle progression	[166]
	SMYD2	Enhance E2F1 transcriptional activity and accelerate cell cycle progression	[23]
	53BP1	Facilitate pRb to integrate cell cycle control and DNA damage response	[171]
	PHF20L1	Negatively regulate E2F-responsive genes for pRb-mediated G1/S checkpoint control	[172]
K873	Set7/9	Repress E2F1-responsive gene expression, arrest cell cycle progression and promote cell differentiation	[167]
K860	SMYD2	Facilitate pRb binding with L3MBTL1	[169]
R787	PRMT4	Disrupt pRb binding with E2F1, enhance E2F1 transcriptional activation and promote cell cycle progression	[173]

ISSN: 1423-0127