Fig. 3
From: SRF: a seriously responsible factor in cardiac development and disease
Chromatin remodeling and its implications on SRF signaling- Epigenetic changes play important roles in facilitating the activation of various transcription factors. After chromatin decondensation facilitated by histone acetyltransferases, the CArG site is available for SRF binding to induce transcription. This effect may be reversed by the action of histone deacetylases, resulting in chromatin condensation and rendering the CArG site unavailable for binding. Furthermore, mechanisms by which CAMK IV or HDAC6 regulates the SRF activation are observed; CAMK IV inhibits HDAC activation and promotes HAT activation, resulting in myocardin-SRF transcriptional activation. In contrast, HDAC6 prohibits MRTF-SRF activation, resulting in suppressed SRF transcriptional activity. HAT histone acetyltransferase; HDAC histone deacetylases; SRF serum response factor; and MRTF myocardin-related transcription factor