Table 4 Summary of disease conditions caused due to SRF modulations

Heart failure

Increased levels of truncated SRF isoform

[10, 142]

Cleavage of SRF by Caspase 3

[143]

Dilated cardiomyopathy

Cleavage of SRF by enteroviral protease 2A

[144]

Decreased SRF Ser¹⁰³ phosphorylation

[149]

Hypertension and arterial stiffness

Vascular smooth muscle cell stiffening due to induction of SRF signaling

[145,146,147]

Conotruncal heart defect

Loss of transcriptional activity due to SRF gene mutations, 821A > G or 880G > T

[148]