Table 3 Association between CLEC18A mRNA level and the (leading edge) genes implicated in the thyroid-stimulated pathway or corticosteroid receptor signaling
Brain (N = 3326) | Pituitary (N = 301) | Thyroid (N = 812) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Gene | ρ | r.2 | P | ρ | r.2 | P | ρ | r.2 | P |
BRD8 | 0.51 | 0.26 | 2.78 × 10–176 | 0.19 | 0.04 | 9.87 × 10–4 | 0.27 | 0.07 | 3.10 × 10–12 |
MED1 | 0.49 | 0.24 | 1.80 × 10–161 | 0.13 | 0.02 | 0.0286 | − 0.07 | 0.01 | 0.0660 |
KLF9 | 0.39 | 0.15 | 1.65 × 10–96 | 0.06 | 0.00 | 0.3288 | − 0.05 | 0.00 | 0.2190 |
CTSL | 0.36 | 0.13 | 2.54 × 10–83 | 0.01 | 0.00 | 0.8353 | − 0.13 | 0.02 | 5.92 × 10–4 |
CTSB | 0.32 | 0.10 | 3.00 × 10–63 | 0.04 | 0.00 | 0.5400 | − 0.12 | 0.02 | 1.46 × 10–3 |
GAS2L1 | 0.31 | 0.10 | 2.55 × 10–61 | 0.24 | 0.06 | 5.31 × 10–5 | 0.05 | 0.00 | 0.1653 |
KIT | 0.31 | 0.10 | 2.65 × 10–61 | 0.13 | 0.02 | 0.0255 | 0.02 | 0.00 | 0.5377 |
PPARGC1A | 0.31 | 0.09 | 3.73 × 10–59 | 0.04 | 0.00 | 0.4553 | − 0.04 | 0.00 | 0.3089 |
GCLM | 0.29 | 0.09 | 6.08 × 10–54 | 0.02 | 0.00 | 0.7377 | − 0.17 | 0.03 | 9.73 × 10–6 |
RDX | 0.20 | 0.04 | 9.01 × 10–26 | 0.22 | 0.05 | 1.96 × 10–4 | − 0.05 | 0.00 | 0.2176 |
GATA1 | 0.17 | 0.03 | 1.71 × 10–19 | 0.08 | 0.01 | 0.1979 | 0.12 | 0.01 | 2.41 × 10–3 |
CTSS | 0.09 | 0.01 | 1.10 × 10–6 | 0.12 | 0.01 | 0.0471 | − 0.00 | 0.00 | 0.9007 |
GHSR | 0.08 | 0.01 | 5.17 × 10–5 | − 0.08 | 0.01 | 0.1551 | − 0.07 | 0.00 | 0.0932 |
LMO2 | 0.03 | 0.00 | 0.1348 | 0.10 | 0.01 | 0.1102 | 0.01 | 0.00 | 0.7788 |
CTSH | − 0.02 | 0.00 | 0.3714 | 0.13 | 0.02 | 0.0320 | 0.12 | 0.01 | 2.48 × 10–3 |
THRB | 0.01 | 0.00 | 0.5759 | 0.15 | 0.02 | 0.0112 | 0.10 | 0.01 | 0.0104 |
ARID1A | 0.51 | 0.26 | 7.20 × 10–175 | 0.25 | 0.06 | 3.04 × 10–5 | − 0.02 | 0.00 | 0.6308 |
JAK2 | 0.46 | 0.21 | 1.73 × 10–136 | 0.09 | 0.01 | 0.1476 | 0.10 | 0.01 | 9.34 × 10–3 |
CRY1 | 0.44 | 0.20 | 3.01 × 10–128 | 0.02 | 0.00 | 0.7632 | 0.09 | 0.01 | 0.0165 |
CLOCK | 0.44 | 0.20 | 1.00 × 10–126 | 0.16 | 0.03 | 6.02 × 10–3 | 0.07 | 0.00 | 0.0906 |
NR3C1 | 0.44 | 0.19 | 2.68 × 10–126 | 0.04 | 0.00 | 0.5404 | 0.09 | 0.01 | 0.0209 |
PPP5C | 0.43 | 0.18 | 3.70 × 10–119 | 0.11 | 0.01 | 0.0717 | − 0.06 | 0.00 | 0.1578 |
PER1 | 0.41 | 0.17 | 9.34 × 10–110 | 0.13 | 0.02 | 0.0254 | 0.07 | 0.00 | 0.0804 |
CALR | 0.37 | 0.13 | 3.60 × 10–85 | 0.04 | 0.00 | 0.5400 | − 0.13 | 0.02 | 1.24 × 10–3 |
CRY2 | 0.37 | 0.13 | 3.96 × 10–85 | 0.11 | 0.01 | 0.0542 | 0.11 | 0.01 | 5.13 × 10–3 |
ARNTL | 0.35 | 0.13 | 5.73 × 10–79 | 0.16 | 0.03 | 5.90 × 10–3 | 0.08 | 0.01 | 0.0352 |
PHB | 0.32 | 0.11 | 5.56 × 10–66 | 0.09 | 0.01 | 0.1534 | − 0.11 | 0.01 | 4.25 × 10–3 |
YWHAH | 0.21 | 0.05 | 1.79 × 10–28 | 0.14 | 0.02 | 0.0223 | − 0.09 | 0.01 | 0.0185 |
NEDD4 | 0.06 | 0.00 | 1.93 × 10–3 | 0.08 | 0.01 | 0.1705 | 0.08 | 0.01 | 0.0304 |
LMO3 | -0.05 | 0.00 | 4.91 × 10–3 | 0.21 | 0.04 | 4.38 × 10–4 | 0.07 | 0.00 | 0.0888 |