Fig. 1

The clinical importance of KRT17 as a prognostic marker in OSCC. A Heatmap analysis of differentially-expressed genes from cDNA microarrays data that were derived from OC3IV (left panel) and OC3 (right panel) OSCC cells. B Datamining analysis of KRT17 mRNA expression in the adjacent normal tissues (N) and OSCC tumor tissues (T) from Oncomine database. C Representative images of IHC staining for the KRT17 protein expression were shown using 3-level pathological ranking of weak, moderate and strong from a set of commercial tissue arrays containing a total of 145 normal and OSCC tissues (top panel). The bottom panel shows a table summarizing statistically the expression differences of KRT17 between normal and OSCC tissues with different pathological stages at I/II or III/IV. D KM plotter survival analysis was performed to examine KRT17 gene expression in a cohort of 307 Head-neck cancer patients (Oncomine database). E Correlation of KRT17 expression to overall survival rates was determined by performing cDNA microarray with 45 OSCC tumor specimens as described in “Methods”