Fig. 8From: DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junctionSchematic illustration of DUSP3 regulation on phosphorylation-mediated degradation of OCLN. DUSP3 regulates OCLN through removing OCLN tyrosine phosphorylation directly and through suppressing FAK as well as FAK-OCLN interaction. Phosphorylated OCLN is ubiquitinated by ITCH and degraded through the proteasome pathwayBack to article page