Skip to main content
Fig. 4 | Journal of Biomedical Science

Fig. 4

From: The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition

Fig. 4

Proximal tubular-specific XBP1 knockout mice exacerbate maladaptive repaired mechanisms following UIRI. a–d qPCR assessment of Kim-1, Adgre1, Tnf-α, and Il-6 mRNA expression levels. N = 6 for each group. Data are expressed as means ± SEM. ***P < 0.001 as compared with XBP1fl/fl sham group, ###P < 0.001 as compared with the indicated group. e Representative images of TUNEL and XBP1 co-stained renal sections in XBP1fl/fl or XBP1cKO mice after 15 days of UIRI surgery. Selected areas indicated TUNEL positive tubules. Scale bar: 50 μm

Back to article page