Fig. 4

A Fold-changes relative to C57BL/6 mice of vegfr2 mRNA in the RVLM in VEGFR2 wild-type (WT) or heterozygous (HZ) mice. Values are mean ± SEM, n = 4 animals per group. *p < 0.05 versus wild-type mice in the Student’s t-test. B, C Survival rate over 36 h following i.p. administration of AOM in VEGFR2 wild-type and heterozygous mice (B), or in C57BL/6 mice that received pretreatment by i.c.v. infusion of an anti-VEGF antiserum (0.004 μg/h) or mouse IgG (0.004 μg/h) (C). n = 10 animals per experimental group