Fig. 6

Fold-changes relative to sham-controls in ATP level (A) or apoptotic cell death determined by cytoplasmic histone-associated DNA fragments (B) in tissues collected from the RVLM in mice that received pretreatment by i.c.v. infusion of mouse IgG (0.004 μg/h) or VEGF Ab (0.004 μg/h) 2, 12 or 24 h after administration of AOM (100 μg/g, i.p.). Samples from sham-controls were obtained randomly at corresponding time-points. Values are mean ± SEM, n = 4 animals per group. *p < 0.05 versus sham-controls group in the Dunnett multiple-range test; ⁺p < 0.05 versus IgG group at corresponding time-points in the Tukey’s multiple-range test