Fig. 7

A Changes in the ratio of aggregated (red fluorescence indicating high mitochondrial membrane potential) to monomer (green fluorescence indicating low mitochondrial membrane potential) JC-1 in cells isolated from the RVLM under 2, 12 or 24 h after administration of AOM (100 μg/g, i.p.). Samples from sham-controls were obtained randomly at corresponding time-points. Values are mean ± SEM, n = 5 animals per experimental group. *p < 0.05 versus sham-controls group in the Dunnett multiple-range test. B Effects of pretreatment by i.c.v. infusion of mouse IgG (0.004 μg/h) or VEGF Ab (0.004 μg/h) on the decrease of mitochondrial membrane potential detected by JC-1 24 h after AOM injection in C57BL/6 mice. Values are mean ± SEM, n = 5 animals per group. *p < 0.05 versus IgG groups in the Student’s t-test