From: CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation
Diseases or functions annotation | Molecules | Number of molecules | -log 10 (p-value) |
---|---|---|---|
Degranulation of cells | ACTN4, ACTR2, ADAM10, ALAD, ANPEP, APP, CALM1, CCT8, CD226, CD47, CD84, CD9, CNN2, COTL1, CYB5R3, CYFIP1, DBNL, DDOST, EEF1A1, ENDOD1, GDI2, GPI, HPSE, HSP90AB1, IQGAP2, LYN, MMRN1, NCKAP1L, PEBP1, PF4, PGRMC1, PTPN6, RAB10, RAB27B, RAB5C, RALB, SELP, SERPINB1, STX11, SYTL4, TGFB1 | 41 | 21.55752 |
Degranulation of phagocytes | ACTR2, ADAM10, ALAD, ANPEP, APP, CCT8, CD226, CD47, CD84, CD9, CNN2, COTL1, CYB5R3, CYFIP1, DBNL, DDOST, EEF1A1, GDI2, GPI, HPSE, HSP90AB1, IQGAP2, LYN, NCKAP1L, PEBP1, PF4, PGRMC1, PTPN6, RAB10, RAB5C, SERPINB1, STX11 | 32 | 16.71444 |
Aggregation of blood platelets | ALOX12, ANXA7, APP, CD47, CD9, CLEC2, GNAQ, GNAZ, GP5, LYN, MPIG6B, MYLK, P4HB, PDIA4, PTPN6, RAB27B, SELP, TGFB1, TREML1, VASP | 20 | 14.64782 |
Degranulation of neutrophils | ACTR2, ADAM10, ALAD, ANPEP, CCT8, CD47, CNN2, COTL1, CYB5R3, CYFIP1, DBNL, DDOST, EEF1A1, GDI2, GPI, HPSE, HSP90AB1, IQGAP2, NCKAP1L, PF4, PGRMC1, PTPN6, RAB10, RAB5C, SERPINB1, STX11 | 26 | 14.03905 |
Degranulation of blood platelets | ACTN4, APP, CALM1 (includes others), CD9, ENDOD1, LYN, MMRN1, PF4, RAB27B, SELP, SYTL4, TGFB1 | 12 | 9.527244 |
Chemotaxis of leukocytes | ADAM10, APP, CD47, CD9, DNM1L, GNAZ, HPSE, HSPD1, JAM3, LYN, MYLK, NCKAP1L, PF4, PLEC, PPIB, PRKCB, PTPN6, SELP, SERPINB1, TGFB1, TXN | 21 | 9.425969 |
Activation of blood platelets | CLEC2, GNAQ, GNB1, GP1BB, GP5, LYN, MPIG6B, PF4, PRKCB, PTPN6, SELP, TREML1, VASP | 13 | 9.191789 |
Cell movement of neutrophils | ADAM10, APP, CD47, CNN2, DNM1L, HSPB1, JAM3, LYN, MYLK, NCKAP1L, PF4, PRKCB, PTPN6, RTN4, SELP, SERPINB1, TGFB1, TXN, VASP | 19 | 8.793174 |
Immune response of cells | ACTR2, ANPEP, ANXA11, APP, CALR, CD226, CD47, CLIC4, CNN2, CORO1C, CYFIP1, DNM1L, EHD1, HSP90B1, HSPB1, IGHA2, KIF2A, LTBP1, LYN, NCKAP1L, PF4, PRKCB, PTPN6, RAB11A, RALB, TGFB1, VASP | 27 | 8.742321 |
Binding of blood platelets | APP, CD226, CD84, CLEC2, FYB1, GP5, JAM3, PPIB, SELP, VASP | 10 | 8.542118 |
Inflammatory response | ADAM10, APP, CD226, CD47, CD84, CD9, DNM1L, FKBP1A, GNAZ, GPX1, HPSE, HSPB1, HSPD1, JAM3, LTBP1, LYN, MAOB, MYLK, NCKAP1L, PF4, PLEC, PPIB, PRDX5, PRKCB, PTPN6, RALB, SELP, SERPINB1, TGFB1, TUBA1C, TXN | 31 | 8.271646 |