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Table 1 Proteins expressed in COVID19-EVs

From: CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation

Diseases or functions annotation

Molecules

Number of molecules

-log 10

(p-value)

Degranulation of cells

ACTN4, ACTR2, ADAM10, ALAD, ANPEP, APP, CALM1, CCT8, CD226, CD47, CD84, CD9, CNN2, COTL1, CYB5R3, CYFIP1, DBNL, DDOST, EEF1A1, ENDOD1, GDI2, GPI, HPSE, HSP90AB1, IQGAP2, LYN, MMRN1, NCKAP1L, PEBP1, PF4, PGRMC1, PTPN6, RAB10, RAB27B, RAB5C, RALB, SELP, SERPINB1, STX11, SYTL4, TGFB1

41

21.55752

Degranulation of phagocytes

ACTR2, ADAM10, ALAD, ANPEP, APP, CCT8, CD226, CD47, CD84, CD9, CNN2, COTL1, CYB5R3, CYFIP1, DBNL, DDOST, EEF1A1, GDI2, GPI, HPSE, HSP90AB1, IQGAP2, LYN, NCKAP1L, PEBP1, PF4, PGRMC1, PTPN6, RAB10, RAB5C, SERPINB1, STX11

32

16.71444

Aggregation of blood platelets

ALOX12, ANXA7, APP, CD47, CD9, CLEC2, GNAQ, GNAZ, GP5, LYN, MPIG6B, MYLK, P4HB, PDIA4, PTPN6, RAB27B, SELP, TGFB1, TREML1, VASP

20

14.64782

Degranulation of neutrophils

ACTR2, ADAM10, ALAD, ANPEP, CCT8, CD47, CNN2, COTL1, CYB5R3, CYFIP1, DBNL, DDOST, EEF1A1, GDI2, GPI, HPSE, HSP90AB1, IQGAP2, NCKAP1L, PF4, PGRMC1, PTPN6, RAB10, RAB5C, SERPINB1, STX11

26

14.03905

Degranulation of blood platelets

ACTN4, APP, CALM1 (includes others), CD9, ENDOD1, LYN, MMRN1, PF4, RAB27B, SELP, SYTL4, TGFB1

12

9.527244

Chemotaxis of leukocytes

ADAM10, APP, CD47, CD9, DNM1L, GNAZ, HPSE, HSPD1, JAM3, LYN, MYLK, NCKAP1L, PF4, PLEC, PPIB, PRKCB, PTPN6, SELP, SERPINB1, TGFB1, TXN

21

9.425969

Activation of blood platelets

CLEC2, GNAQ, GNB1, GP1BB, GP5, LYN, MPIG6B, PF4, PRKCB, PTPN6, SELP, TREML1, VASP

13

9.191789

Cell movement of neutrophils

ADAM10, APP, CD47, CNN2, DNM1L, HSPB1, JAM3, LYN, MYLK, NCKAP1L, PF4, PRKCB, PTPN6, RTN4, SELP, SERPINB1, TGFB1, TXN, VASP

19

8.793174

Immune response of cells

ACTR2, ANPEP, ANXA11, APP, CALR, CD226, CD47, CLIC4, CNN2, CORO1C, CYFIP1, DNM1L, EHD1, HSP90B1, HSPB1, IGHA2, KIF2A, LTBP1, LYN, NCKAP1L, PF4, PRKCB, PTPN6, RAB11A, RALB, TGFB1, VASP

27

8.742321

Binding of blood platelets

APP, CD226, CD84, CLEC2, FYB1, GP5, JAM3, PPIB, SELP, VASP

10

8.542118

Inflammatory response

ADAM10, APP, CD226, CD47, CD84, CD9, DNM1L, FKBP1A, GNAZ, GPX1, HPSE, HSPB1, HSPD1, JAM3, LTBP1, LYN, MAOB, MYLK, NCKAP1L, PF4, PLEC, PPIB, PRDX5, PRKCB, PTPN6, RALB, SELP, SERPINB1, TGFB1, TUBA1C, TXN

31

8.271646

  1. The mass spectrum analysis was performed using the LTQ Orbitrap XL mass spectrometer (Thermo Fisher Scientific Inc.) and the proteomics data were further analyzed by Ingenuity Pathways Analysis (IPA) software. The unique proteins present in EVs form COVID-19 patients (COVID19-EVs) were listed in the table according to the result of IPA analysis