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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Generational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit

Fig. 2

Synaptic GABAAR levels and inhibitory transmission in two generations of the VPA-induced offspring. a Representative western blot profile and the protein levels of GABAAR \({\upbeta }\)3 subunit in the synaptoneurosomes from the amygdala. n = 6 rats from three or four litters for each condition. b Top, Representative IPSC traces at different stimuli. Scale bars, 100 pA, 50 ms. Bottom, input–output curves of IPSC in response to a series of increasing stimulus intensities. n = 9–10 cells from 4–5 rats from three or four litters for each condition. c Top, Representative IPSC traces at different holding potentials. Scale bars, 100 pA, 50 ms. Bottom, reversal potential of IPSCs in response to various holding potential ranging from − 60 to 60 mV. n = 8–10 cells from 4–5 rats from three or four litters for each condition. d Representative mIPSCs traces from the BLA pyramidal neurons. Scale bars, 100 pA, 50 ms. e, f Bar graphs show average mIPSC amplitudes (e) and frequency (f) measured from the BLA pyramidal neurons. g, h Cumulative probability of mIPSC amplitudes (g) and frequency (h) measured from the BLA pyramidal neurons. n = 8–9 cells from 4–5 rats from three or four litters for each condition. Data are presented as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001 vs. indicated control; one-way ANOVA or two-way rmANOVA with Bonferroni post-hoc

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