Skip to main content
Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment

Fig. 6

Secretory autophagy mediated release of pro-tumor factors in TME contributes to cancer progression and tumor metastasis. Both cancer and stromal cells are able to release pro-tumor factors via secretory autophagy. Autophagy-mediated release of type I collagen and fibronectin from stellate cells as well as Wnt5A, MMP2 and TGF-β1 from cancer-associated fibroblast (CAF) or TGF-β1 from tumor-associated macrophage (TAM) facilitate tumor metastasis. In addition, autophagy-regulated release of IL-8 and IL-6 derived from CAFs or HMGB1 from TAM and cancer cells leads to inflammation and cancer progression. Furthermore, TAM produced galectin-1 via secretory autophagy creates an immunosuppressive TME and enhances tumor growth, which altogether leads to cancer progression. ECM Extracellular matrix

Back to article page

Journal of Biomedical Science

ISSN: 1423-0127