Table 3 Clinical trials of EVs for development of anticancer treatment
Cancer type | Title of the trial | Phase | State | Number of participants | ClinicalTrials.gov identifier |
|---|---|---|---|---|---|
Lung Cancer | Phase II trial of a vaccination with tumor antigen-loaded dendritic cell-derived exosomes on patients with unresectable non-small cell lung cancer responding to induction chemotherapy | II | Completed | 41 | NCT01159288 [187] |
Pancreatic Cancer | Phase I study of mesenchymal stromal cells-derived exosomes with KrasG12D siRNA for metastatic pancreas cancer patients harboring KrasG12D mutation | I | Ongoing | Recruiting | NCT03608631 [186] |
Colon Cancer | Phase I clinical trial investigating the ability of plant exosomes to deliver curcumin to normal and malignant colon tissue | I | Ongoing | Recruiting | NCT01294072 |
Head and Neck Cancer | Preliminary clinical trial investigating the ability of plant exosomes to abrogate oral mucositis induced by combined chemotherapy and radiation in head and neck cancer patients | I | Ongoing | 60 | NCT01668849 |