Fig. 2

HLA-B*13:01 protein directly presents DDS without intracellular metabolism and the overall structure of HLA-B*13:01-β2M-peptide. A The crystal structure of HLA-B*13:01-β2M-peptide was determined at resolution of 1.50 Å. Ribbon representation of HLA-B*13:01-β2M and stick representation of the peptide. In HLA-B*13:01, HLA is shown in green, β2M is shown in gray and the peptide is shown in yellow. The 2Fo-Fc map of the peptide contoured at 1.2 σ. B DDS potentially binds to the F pocket of binding groove due to a constant RMSDs value. C The pocket where the DDS is located in HLA-B*13:01. Electrostatic surface representation of the pocket of DDS and the residues that make up this pocket are shown as stick in HLA-B*13:01