Table 1 Clinical characteristics of twelve patients and ten tolerant controls with dapsone-induced hypersensitivity reactions
Characteristic | Eleven DDS-DIHS and one DDS-SJS patients | Tolerant patient (n = 10) |
|---|---|---|
Age, y (mean ± SD) | 43.1 ± 17.0 | 46.7 ± 13.5 |
Sex, M:F | 5:7 | 5:5 |
Fever ≥ 38.5 °C, n (%) | 12 (100%) | 0 (0%) |
Typical skin eruptions, n (%) | ||
 Exfoliative dermatitis | 2 (16.7%) |  |
 Erythrodema | 10 (83.3%) |  |
Enlarged lymph nodes, n (%) | ||
 ≥ 2 sites | 12 (100%) |  |
 ≥ 1 cm |  | |
Eosinophilia, n (%) | ||
 Grade 2 (≥ 1500/µL) | 6 (50%) |  |
 Grade 1 (700–1499/µL) | 6 (50%) |  |
Mucosal involvement, n (%) | ||
 Oral | 2 (16.7%) |  |
 Conjunctival | 2 (16.7%) |  |
 Genital | 2 (16.7%) |  |
Internal organ involvement, n (%) | ||
 Liver | 12 (100%) |  |
 Kidney | 3 (25.0%) |  |
EBV/HHV6 reactivation*, n (%) | ||
 None | 7 (58.3%) |  |
 n.a. | 5 (41.7%) |  |
HLA-B*13:01 positive | 12 (100%) | 3 (30%) |
DIHS/DRESS score* | ||
 6 | 3 (25%) |  |
 5 | 3 (25%) |  |
 4 | 6 (50%) |  |