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Table 3 Distribution of phylogenetic groups and virulence factor (VF) genes in relation to papG alleles among E. coli isolates from reproductive-age women with cystitis

From: Distribution of papG alleles among uropathogenic Escherichia coli from reproductive age women

Trait

Number (%) of isolates

P valued

Phylogenetic Group or VFa gene

papG negb

(n = 117)

papG posc

(n = 190)

papGII + 

(n = 52)

papGIII + 

(n = 95)

papGIV + 

(n = 4)

papGII + papGIII

(n = 21)

papG neg vs. papG pos

papGII vs

papGIII

A

2 (2)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

eNS

NS

B1

2 (2)

0 (0)

0 (0)

2 (2)

0 (0)

0 (0)

NS

NS

B2

82 (70)

149 (78)

52 (100)

86 (91)

0 (0)

21 (100)

0.037

0.027

C

6 (5)

4 (2)

2 (4)

4 (4)

2 (5)

0 (0)

NS

NS

D

13 (11)

14 (7)

2 (4)

12 (13)

0 (0)

1 (5)

NS

NS

E

7 (6)

7 (4)

1 (2)

4 (4)

1 (25)

0 (0)

NS

NS

F

3 (3)

12 (6)

1 (2)

5 (5)

1 (25)

1 (5)

NS

NS

Clade 1

2 (2)

4 (2)

1 (2)

1 (1)

0 (0)

0 (0)

NS

NS

afa

23 (20)

10 (5)

0 (0)

3 (3)

0 (0)

9 (42)

 < 0.001

NS

bmaE

0 (0)

0 (0)

0 (0)

5 (5)

0 (0)

0 (0)

NS

NS

cnf1

22 (19)

108 (57)

23 (44)

35 (37)

2 (50)

18 (86)

 < 0.001

NS

fimH

108 (92)

190 (100)

52 (100)

93 (98)

4 (100)

21 (100)

 < 0.001

NS

focG

42 (36)

78 (41)

18 (35)

21 (22)

1 (25)

21 (100)

NS

NS

fyuA

73 (62)

110 (58)

26 (50)

39 (41)

2 (50)

18 (86)

NS

NS

gafD

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

2 (9)

NS

NS

hlyA

45(38)

105 (55)

35 (67)

44 (46)

2 (50)

18 (86)

0.005

0.016

iutA

63 (54)

139 (73)

44 (85)

49 (52)

2 (50)

19 (92)

 < 0.001

 < 0.001

kpsII

47 (40)

116 (61)

30 (58)

30 (32)

2 (50)

16 (77)

0.003

0.003

kpsIII

6 (5)

6 (3)

2 (4)

0 (0)

0 (0)

(23)

NS

NS

papAH

78 (67)

156 (82)

48 (92)

77 (81)

3 (75)

21 (100)

0.002

NS

papC

77 (66)

162 (85)

49 (94)

74 (78)

3 (75)

21 (100)

 < 0.001

NS

papEF

75 (64)

154 (81)

49 (94)

77 (81)

3 (75)

21 (100)

0.001

NS

sfaS

21 (18)

63 (33)

18 (35)

25 (26)

1 (25)

16 (77)

0.004

NS

traT

85 (73)

148 (78)

37 (72)

77 (78)

3 (75)

21 (100)

NS

NS

ompT

78 (67)

137 (72)

32 (62)

60 (63)

3 (75)

17 (82)

NS

NS

usp

81 (69)

135 (71)

30 (58)

66 (69)

3 (75)

18 (86)

NS

NS

f,gVF score (Median, range)

3 (1–7)

5 (2–13)

7 (3–12)

5 (1–10)

6 (1–9)

14(10–13)

0.001

0.016

  1. aThe 22 virulence factors analyzed were; papA, P fimbriae structural subunit; papC, P fimbriae assembly; papEF, fimbriae tip pilins; papG, P fimbriae adhesin (and alleles I, II and III); sfaS, S fimbriae; focG, F1C fimbriae; afa/draBC, Afimbrial adhesin (Dr-binding adhesin); fimH, type 1 fimbriae; hlyA, hemolysin; cnf1, cytotoxic necrotizing factor type1; fyuA, ferric yersiniabactin receptor; iutA, aerobactin receptor; iroN, catecholate siderophore receptor; kpsMTII group 2 capsule (with K1 and K2 variants); kpsMTIII, group 3 capsule; traT, serum-resistance associated; ompT, outer membrane protein T (protease); bmaE, M fimbriae; gafD, (G) fimbriae
  2. bpapG neg, papG gene negative (for all alleles)
  3. cpapG pos, papG gene positive (for any allele)
  4. dP values (by Fisher’s exact test) are shown where P < 0.05
  5. eNS, not statistically significant, P > 0.05
  6. fVF score, sum of all VF genes tested, with pap operon genes counted as a unit
  7. gP values by Mann–Whitney test are shown where P < 0.05