Fig. 1From: The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implicationsTXNDC5 contributes critically to the development of organ fibrosis through its PDI activity mediated by TRX domains. Global or targeted deletion of Txndc5 prevents or halts fibrosis progression, as reflected by a reduction of fibrillar collagen deposition in internal organs including heart, lung, kidney and liverBack to article page