Organ fibrosis | TXNDC5 downstream signaling pathway |
---|---|
Cardiac fibrosis [25] | 1. Non-canonical TGFβ pathway: JNK signaling |
2. Facilitating folding of ECM protein, such as collagen and fibronectin | |
Pulmonary fibrosis [26] | 1. Canonical TGFβ pathway: SMAD3 signaling |
2. Non-canonical TGFβ pathway: JNK and ERK signaling | |
3. Post-translationally stabilizing TGFβR1 protein | |
Renal fibrosis [27] | 1. Canonical TGFβ pathway: SMAD3 signaling |
2. Post-translationally stabilizing TGFβR1 protein | |
Liver fibrosis [28] | 1. Non-canonical TGFβ pathway: JNK and STAT3 signaling |