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Table 1 TGFβ-ATF6-TXNDC5 signaling axis triggers various downstream fibrogenic signaling pathways in different organs

From: The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications

Organ fibrosis

TXNDC5 downstream signaling pathway

Cardiac fibrosis [25]

1. Non-canonical TGFβ pathway: JNK signaling

2. Facilitating folding of ECM protein, such as collagen and fibronectin

Pulmonary fibrosis [26]

1. Canonical TGFβ pathway: SMAD3 signaling

2. Non-canonical TGFβ pathway: JNK and ERK signaling

3. Post-translationally stabilizing TGFβR1 protein

Renal fibrosis [27]

1. Canonical TGFβ pathway: SMAD3 signaling

2. Post-translationally stabilizing TGFβR1 protein

Liver fibrosis [28]

1. Non-canonical TGFβ pathway: JNK and STAT3 signaling