Fig. 2From: Protein O-GlcNAcylation and the regulation of energy homeostasis: lessons from knock-out mouse modelsO-GlcNAcylation depends on the energy status of the cell. The hexosamine biosynthesis pathway results in the formation of UDP-GlcNAc, which is used by OGT to O-GlcNAcylate proteins. UDP-GlcNAc is at the crossroads of different cellular metabolisms (glucose, amino acids (glutamine), fatty acids (acetyl-CoA) and nucleotides (UTP)) and therefore reflects the energy status of the cell. HK Hexokinase, GPI Glucose-6-phosphate isomerase, GFAT Glutamine-6-P amidotransferase, GNA1 Glucosamine 6-P acetyltransferase, PGM3 Phosphoacetylglucosamine mutase, UAP1 UDP-N-Acetylhexosamine pyrophosphorylase 1, OGT O-GlcNAc transferase, OGA O-GlcNAcaseBack to article page