Fig. 3

Lessons from OGT and OGA knock-out mice. A Tissue-specific OGT-KO mice have brought important insights into the role of O-GlcNAcylation in the regulation of energy homeostasis. B Only few tissue-specific OGA-KO mice have been developed to date, and contradictory results have been obtained for the regulation of energy homeostasis in two different models of mice with global OGA haploinsufficiency