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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

Fig. 4

Diagrammatic illustration of mRNA-LNPs complex preparation and testing. A Synthesis of IVT mRNA. 1. Restriction enzyme digestion for DNA plasmid linearization; 2. Co-transcriptional capping of IVT; 3. DNase treatment and cellulose-based purification of IVT mRNA. B Schematic representation of the LNPs-encapsulated mRNA. C In vitro assay of protein expression from mRNA-LNPs. D Immunogenicity assessment of mRNA-LNPs in vivo

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Journal of Biomedical Science

ISSN: 1423-0127