Fig. 3
From: Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Schematic representation of ARID1A-based synthetic lethality. Synthetic lethal interaction or synthetic lethality between two genes occurs when their simultaneous inactivation results in cell death. In this illustration, two synthetic lethal partners are ARID1A and a hypothetical gene ‘X’ or a pathway that gene ‘X’ regulates. In a malignant cell having ARID1A loss (top green cell), viability is dependent upon its essential gene ‘X’. Loss of gene ‘X’ either by inactivating mutation or using drug/inhibitor results in cell death. Illustration created using Biorender.com