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Fig. 8 | Journal of Biomedical Science

Fig. 8

From: Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages

Fig. 8

The diverse localization of LGp40 alters macrophage phenotypes with its high glycolytic activity. LGp40 adheres to plasminogen on macrophages and changes the metabolism of allergic M2 macrophage from oxidative phosphorylation to glycolysis, including macrophage polarization toward M1. The moonlighting LGp40 modulates macrophage reprogramming with dehydrogenase activities to alleviate the progression of allergic inflammation of airways. (The graph was generated using BioRender software.)

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