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Table 2 Candidate HLA class I restricted HPV18 E6-specific CTL epitope predicted by NetMHCpan 4.1 algorithm

From: Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice

Overlapping peptide

HLA element

Epitope length

Epitope sequence

Position

Percentile Rank

E6.5 (aa21-35)

A*02:01

8

SLQDIEIT

aa24-31

12.58

9

SLQDIEITC

aa24-32

0.46

10

SLQDIEITCV

aa24-33

0.11

E6.19 (aa91-105)

A*02:01

8

GLYNLLIR

aa97-104

11.13

9

GLYNLLIRC

aa97-105

0.57

10

KLTNTGLYNL

aa92-101

0.99

E6.20 (aa96-110)

A*02:01

8

GLYNLLIR

aa97-104

11.13

9

GLYNLLIRC

aa97-105

0.57

10

GLYNLLIRCL

aa97-106

0.59

E6.17(aa81-95)

A*11:01

8

VYGDTLEK

aa85-92

3.69

9

SVYGDTLEK

aa84-92

0.002

10

DSVYGDTLEK

aa83-92

0.51

E6.17(aa81-95)

A*24:02

8

YGDTLEKL

aa86-93

2.95

9

VYGDTLEKL

aa85-93

0.03

10

SVYGDTLEKL

aa84-93

0.61

E6.5 (aa21-35)

B*40:02

8

QDIEITCV

aa26-33

2.76

9

QDIEITCVY

aa26-34

4.19

10

QDIEITCVYC

aa26-35

14.19

  1. Rank threshold for strong binding peptides: 0.500. Rank threshold for weak binding peptides: 2.000. Boldfaced peptides were chosen as predicted epitopes