Fig. 1

Schematic diagram of the study design. A Data of human samples of colorectal adenocarcinoma were obtained from public databases (see Additional file 1: Table S1 and Supplementary Methods). B A risk model is established by integrating module analysis and Cox regression. C The risk model is evaluated by independent prognosis analysis and a nomo decision tree is established by integrating risk score and other clinical parameters. D The risk model is validated in another independent large cohort of colon cancer; molecular classification, therapy evaluation and pathway enrichment analysis of the risk genes is investigated. E Tumor microenvironment immune activity is correlated with the risk model