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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Establishment and evaluation of module-based immune-associated gene signature to predict overall survival in patients of colon adenocarcinoma

Fig. 2

Module-trait relationships identified by WGCNA analysis from the transcriptome data of COAD patients. A Each colored module represents a network of genes with correlated expression built using TCGA-COAD samples after WGCNA quality filter and outliers’ removal (n = 283). “MEgrey” is unassigned gene sets which could not fit anywhere. Eight clinical traits (survival time, survival event, age, gender, stage, T, M, N) were evaluated for correlated gene expression networks. The correlation coefficients and p values are based on biweight midcorrelation. The correlation coefficients by modules and traits are shown at the top of each cell. The corresponding p-values for each module displayed at the bottom of each cell within parentheses. The rows are colored based on the correlation of the module with the indicating traits: red for positive and blue for negative correlation. Gene number and enriched biology process in each module of gene networks are displayed in the corresponding row on the right side. B Interaction network of module tan and module turquoise, adjacency threshold for including edges is 0.01 (nTan = 78; nTurquoise = 638). Connection strength between two genes is measured by the edge weight in the Topological Overlap Matrix, higher value refers to a stronger co-expression of genes, which is represented by the line transparency in the network. The network is organized by the force-directed layout, highly connected genes is centered in the network. The risk model genes (n = 23) is enlarged in the network

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