Table 1 Cytokines and chemokines modulation in SLN during cancer progression
From: Reprogramming of sentinel lymph node microenvironment during tumor metastasis
Cancer type | Proteins and nucleic acids | Effect | Refs. |
|---|---|---|---|
Cytokines | Â | Â | Â |
| Â | COX-2 | Macrophages phenotype changes | Â |
| Â | GM-CSF | Proliferation and differentiation of DCS | [5] |
Melanoma | IFN-γ | Production of cytotoxic cells | [122] |
| Â | IL-10 | Dampens acquired Th1 and Th2 cell cytokine production | [123] |
| Â | VEGF-A | Lymphangiogenesis | Â |
Breast cancer | Il-12p40 | Â | [124] |
|  | IFN-γ |  |  |
NSCLC | TGF-β | Decreased DCS concentration | [53] |
Chemokines | Â | Â | Â |
Oral, breast, | CXCR3 | Tumor-LEC chemotaxis | [100] |
melanoma | CXCR4-CXCL12 | Tumor-LEC chemotaxis | [126] |
Melanoma | CCR8-CCL1 | Tumor-LEC chemotaxis | [125] |
Gastric, colorectal, | CCR7-CCL19/MIP-3β | Tumor-LEC chemotaxis | [127] |
breast cancer | CCR7-CCL21/6Ckine | Tumor-LEC chemotaxis | [128] |