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Table 2 SLN reprogramming with different cargo in EVs

From: Reprogramming of sentinel lymph node microenvironment during tumor metastasis

Cancer type

Cargo in EVs

Effect

Refs.

OSCC

Lamin-332

Lymphangiogenesis

[136]

Colorectal cancer

IRF-2

Ingested by macrophage/induce VEGF-C expression

[137]

Breast cancer

Palmitoylated protein

NFκB activation via TLR-2 on macrophages

[139]

MDCK (normal kidney)

PDPN

Lymphangiogenesis

[140]

Melanoma, lung cancer,

EGFR

Angiogenesis

[141]

colorectal cancer

   

Cervical cancer

miR221-3p

Induce LYVE-1 expression

[142]

Melanoma

PEDF

Recruitment of MDSCs/activation of TAM

[132, 143]

Melanoma

miR-9

Regulate angiogenesis via JAK-STAT

[144]