From: Reprogramming of sentinel lymph node microenvironment during tumor metastasis
Cancer type | Cargo in EVs | Effect | Refs. |
---|---|---|---|
OSCC | Lamin-332 | Lymphangiogenesis | [136] |
Colorectal cancer | IRF-2 | Ingested by macrophage/induce VEGF-C expression | [137] |
Breast cancer | Palmitoylated protein | NFκB activation via TLR-2 on macrophages | [139] |
MDCK (normal kidney) | PDPN | Lymphangiogenesis | [140] |
Melanoma, lung cancer, | EGFR | Angiogenesis | [141] |
colorectal cancer | Â | Â | Â |
Cervical cancer | miR221-3p | Induce LYVE-1 expression | [142] |
Melanoma | PEDF | Recruitment of MDSCs/activation of TAM | |
Melanoma | miR-9 | Regulate angiogenesis via JAK-STAT | [144] |