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Table 3 Association of bacteria with clinicopathological features and genomic alterations

From: Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas

  

Prevotella intermedia

Fusobacterium nucleatum

P. intermedia + F. nucleatum

Presence

Absence

OR (95% CI)

Presence

Absence

OR (95% CI)

Co-existence

Others

OR (95% CI)

Gender

Male

14

54

1.30 (0.50, 3.39)

34

34

1.40 (0.66, 2.95)

13

55

2.03 (0.67, 6.14)

Female

8

40

 

20

28

 

5

43

 

Location

Left

14

61

0.95 (0.36, 2.49)

32

43

0.64 (0.30, 1.38)

14

61

2.12 (0.65, 6.94)

Right

8

33

 

22

19

 

4

37

 

TNM stage

Late (III/IV)

12

37

2.05 (0.79, 5.35)

28

21

2.19 (1.03, 4.64)

11

38

2.89 (0.99, 8.48)

Early (0/I/II)

9

57

 

25

41

 

6

60

 

Primary tumor

T3/T4

16

69

0.97 (0.34, 2.77)

40

45

1.08 (0.47, 2.46)

14

71

1.33 (0.40, 4.40)

T0/T1/T2

6

25

 

14

17

 

4

27

 

Lymph node

Yes

12

37

2.05 (0.79, 5.35)

28

21

2.19 (1.03, 4.64)

11

38

2.89 (0.99, 8.48)

Involvement

No

9

57

 

25

41

 

6

60

 

Distant metastasis

Yes

4

5

3.96 (0.97,16.19)

7

2

4.47 (0.89, 22.51)

4

5

5.31 (1.27, 22.20)

No

18

89

 

47

60

 

14

93

 

CIN status

High

13

46

1.75 (0.57, 5.41)

29

30

0.97 (0.42, 2.21)

12

47

2.04 (0.60, 6.90)

Low or stable

5

31

 

18

18

 

4

32

 

Chr20 amplification

Yes

12

54

0.85 (0.29, 2.55)

30

36

0.59 (0.24, 1.42)

11

55

0.96 (0.30, 3.06)

No

6

23

 

17

12

 

5

24

 

Chr13q amplification

Yes

12

37

2.16 (0.74, 6.35)

27

22

1.60 (0.71, 3.59)

11

38

2.37 (0.75, 7.46)

No

6

40

 

20

26

 

5

41

 

MSI status

High

3

5

2.76 (0.59, 12.83)

6

2

3.15 (0.60, 16.49)

3

5

3.28 (0.70, 15.42)

Low or stable

15

69

 

41

43

 

13

71

 

APC mutation

Yes

9

35

0.96 (0.33, 2.81)

19

25

0.50 (0.21, 1.20)

7

37

0.71 (0.23, 2.18)

No

8

30

 

23

15

 

8

30

 

KRAS mutation

Yes

7

24

1.20 (0.40, 3.55)

17

14

1.26 (0.52, 3.09)

5

26

0.79 (0.24, 2.57)

No

10

41

 

25

26

 

10

41

 

TP53 mutation

Yes

13

42

1.78 (0.52, 6.09)

28

27

0.96 (0.38, 2.42)

13

42

3.87 (0.81, 18.58)

No

4

23

 

14

13

 

2

25

 
  1. OR odds ratio, CI confidence interval, CIN chromosomal instability, MSI microsatellite instability