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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors

Fig. 1

The molecular mechanisms driving the efficacy of and resistance to PARPi. a PARPi compete with NAD+ to inhibit PARylation of PARP target proteins and induce PARP trapping on damaged DNA, which in turn results in replication fork collapse and accumulation of toxic DSBs in HR-deficient cells. b General PARPi-resistant mechanisms. (1) PARPi resistance caused by phosphorylation and binding partners of PARP1. (2) Restoration of HR capacity occurs via re-expressing functional HR repair proteins (upper panel) or acquiring DNA end resection (lower panel)

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Journal of Biomedical Science

ISSN: 1423-0127