Fig. 2From: The pathogenesis of coronavirus-19 diseaseDiffuse alveolar damage is characterized by hyaline membranes (asterisk) resulting from AT1 cell necrosis, as well as exuberant regeneration of AT2 cells during the first week following infection (A). Hyaline membranes and epithelial cells show immunoreactivity for spike protein (asterisk) using a red chromogen. B These areas also contain viral spike RNA (asterisk) as demonstrated with in situ hybridization using a brown chromogen (C). Such cases were also positive by real time polymerase chain reaction (not shown) (A hematoxylin and eosin stain)Back to article page