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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma

Fig. 6

The combination of ZVI@CMC and radiation treatment boosted the anti-tumor efficacy. A MTT assay of ESCC resistant cells treated with the combination of ZVI@CMC and radiation treatment for 72 h. B Tumor growth of KYSE510-R xenografts treated with ZVI@CMC (indicated as arrow) and/or radiation (indicated as triangle) treatment. C, D Tumor size (C) and tumor weight (D) were measured at the end of the experiment. E Immunohistochemistry staining revealed the expression of DNMT1, DNMT3B, SOX17, NRF2, GPX4, and 4-HNE in tumor tissues from KYSE510-R xenografts which were treated with ZVI@CMC and/or radiation treatment. Data represents mean ± s.e.m. ns: non-significant; *p < 0.05; **p < 0.01; ***p < 0.001

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