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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa

Fig. 3

Perturbations of the peptidoglycan biosynthesis pathway. The polymyxin B/rifampicin combination significantly upregulated intracellular metabolites and differentially expressed genes (DEGs) associated with peptidoglycan biosynthesis over the first 4 h of treatment. PB polymyxin B, RIF rifampicin, COMBO polymyxin B/rifampicin combination. Red and * indicates the significantly changed metabolites and DEGs that were identified with > 1.0 and < − 1.0 log2FC and FDR ≤ 0.05

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