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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa

Fig. 4

Perturbations of the LPS modification pathway at 1 h. Polymyxin B alone significantly upregulated arnA (rxn07473, rxn07475), arnB (rxn07474), arnC (rxn07476) and UDP-glucoronate causing the addition of 4-aminoarabinose to the lipid A of LPS. PB, polymyxin B; RIF, rifampicin; COMBO, polymyxin B/rifampicin combination. Red and * indicate the significantly changed metabolites and differentially expressed genes that were identified with > 1.0 and < − 1.0 log2FC and FDR ≤ 0.05

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Journal of Biomedical Science

ISSN: 1423-0127