Table 1 Common differentially expressed genes (> 1.0 and < − 1.0 log2FC and FDR ≤ 0.05) induced by polymyxin B (PB) alone, rifampicin (RIF) alone and the combination (COMBO) at 24 h
Locus tag (gene name) | Product description | Expression ratio (log2) | ||
|---|---|---|---|---|
PB | RIF | COMBO | ||
PA1483 (CycH) | Cytochrome c-type biogenesis protein CycH | − 1.76 | − 1.87 | − 2.01 |
PA2006 | Major facilitator superfamily transporter | 2.52 | 3.19 | 3.29 |
PA2006 (NuoG) | NADH-quinone oxidoreductase subunit G | − 1.33 | − 1.63 | − 1.88 |
PA2993 | Hypothetical protein | − 1.66 | − 1.94 | − 1.99 |
PA3495 (Nth) | Endonuclease III | − 1.63 | − 2.02 | − 1.66 |
PA3559 | Nucleotide sugar dehydrogenase | − 2.46 | − 3.04 | − 3.42 |
PA3650 (Dxr) | 1-Deoxy-d-xylulose 5-phosphate reductoisomerase | − 1.78 | − 2.78 | − 3.19 |
PA3800 | OM protein assembly factor BamB | − 1.67 | − 1.91 | − 1.81 |
PA3801 | Hypothetical protein | − 1.78 | − 2.27 | − 2.21 |
PA4251 (RplE) | 50S ribosomal protein L5 | − 2.53 | − 3.01 | − 2.88 |
PA4252 (RplX) | 50S ribosomal protein L24 | − 2.60 | − 3.08 | − 3.22 |
PA4253 (RplN) | 50S ribosomal protein L14 | − 2.25 | − 2.94 | − 3.16 |
PA5001 | Hypothetical protein | − 1.43 | − 1.96 | − 1.98 |
PA5007 | Hypothetical protein | − 2.09 | − 2.16 | − 2.14 |
PA5365 (PhoU) | Phosphate uptake regulatory protein PhoU | − 1.66 | − 2.25 | − 2.07 |