Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa

Table 3 Differentially expressed genes (> 1.0 log₂FC and FDR ≤ 0.05) at 24 h associated with amino acid metabolism induced by rifampicin (RIF) monotherapy and the polymyxin B/rifampicin combination (COMBO)

Metabolism	RIF	Log₂FC	COMBO	Log₂FC
Leucine degradation	liuA	2.28	liuA	1.76
Leucine degradation	liuB	2.12	liuB	1.76
Tyrosine degradation	hpd	3.38	phhC	1.79
	maiA	2.49	hpd	3.26
	fahA	3.33	maiA	2.98
			fahA	3.99

ISSN: 1423-0127