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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation

Fig. 5

PTEN transcriptionally regulates DUSP19 to dephosphorylate VEGFR3 in pNETs. A The phospho-signal of the phospho-VEGFR3 peptide was not changed by the addition of recombinant PTEN. B The protein expression levels of phosphorylated VEGFR3, VEGFR3, DUSP19, and PTEN in QGP-1 cells with PTEN knockdown or overexpression (upper panel). The mRNA expression levels of DUSP19 in QGP-1 cells with PTEN knockdown or overexpression (lower panel). C The protein levels of phosphorylated VEGFR3, VEGFR3, phosphorylated AKT, AKT, DUSP19, and PTEN in QGP-1 cells overexpressing wild-type, lipid phosphatase-deficient (G129E), protein phosphatase-deficient (Y138L) and both lipid and protein phosphatase-deficient (C124S) PTEN. D The protein level of phosphorylated VEGFR3 in QGP-1 cells with and without DUSP19 overexpression (left). The protein level of phosphorylated VEGFR3 in QGP-1 cells with and without PTEN overexpression and in QGP-1 cells with PTEN overexpression and DUSP19 knockdown (right)

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