Skip to main content
Fig. 7 | Journal of Biomedical Science

Fig. 7

From: PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation

Fig. 7

PTEN loss promotes the invasiveness of pNETs in vivo. A The tumor growth curves of QGP-1 xenograft-bearing mice in the shLuc control, shPTEN control, shPTEN + MAZ51, and shPTEN + trametinib groups. B Representative H&E images of QGP-1 xenografts with (shPTEN) and without (shLuc) PTEN loss and treated with MAZ51 (shPTEN + MAZ51) or trametinib (shPTEN + trametinib). Score 0: confinement of the tumor to the original area; score 1: focal invasion into the peripheral fibrofatty tissue; score 2: multifocal invasion into the peripheral fibrofatty tissue; score 3: invasion into muscular bundles. C Representative IHC staining of SLUG in xenografts with high (QGP-1/shPTEN) or low (QGP-1/shPTEN + MAZ51) SLUG expression

Back to article page