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Fig. 9 | Journal of Biomedical Science

Fig. 9

From: Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells

Fig. 9

Schematic summary of thrombin-induced IL-8/CXCL8 expression signaling pathway involving DCLK1 in lung epithelial cells. It has previously been revealed that thrombin-induced ERK activation increases IKKα/β phosphorylation, which promotes p65 to translocate to the nucleus from the cytosol, resulting in IL-8/CXCL8 expression. In this report, DCLK1 is involved in thrombin-induced IL-8/CXCL8 expression via ERK and then mediates the activation of RhoA and YAP. Once YAP is activated, it moves to nucleus from cytosol, where it binds to the transcription factor p65, increasing IL-8/CXCL8 expression in human lung epithelial cells. This image was created with BioRender (https://biorender.com/)

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