Fig. 6

SR9009 and IL-6 neutralized antibody alleviated the effect of circadian rhythm disruption on decidualization and pregnancy outcome in mice. a–c Relative mRNA level of Rev-erbα, IL-6 and PGR in DSCs from control mice and sleep disturbance mice with SR9009 or IL-6 neutralized antibody treatment. d The protein level of PR, C/EBPβ, IL-6 and Rev-erbα in DSCs from control mice and sleep disturbance mice with SR9009 or IL-6 neutralized antibody treatment. Relative protein levels were normalized to β-Tubulin. e–g The Relative mRNA level of Dtprp, Wnt4 and Bmp2 in DSCs from control mice and sleep disturbance mice with SR9009 or IL-6 neutralized antibody treatment. h The representative pictures of pregnancy outcomes of control mice and sleep disturbance mice with SR9009 or IL-6 neutralized antibody treatment. i The number of implantation site, abortion rate, fetal weight and placental weight of control mice and sleep disturbance mice with SR9009 or IL-6 neutralized antibody treatment. mNS represented mouse with normal sleep. mSD represented mouse with sleep disturbance. Data represented Mean ± SEM. Statistical analysis was performed using Student’s t‐test. **P < 0.01, ***P < 0.001