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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling

Fig. 3

POSTN expression promotes ovarian tumor growth and metastasis in vivo. A SKOV3 cells were stably transfected with a control or a POSTN-expressing plasmid and inoculated into SCID mice s.c. for 4 weeks (n = 5 mice in each group). The volume of the s.c. xenograft tumors was measured each week. *p < 0.05. B POSTN overexpression enhanced the growth of SKOV3 cells in the i.p. mouse model (n = 6 mice in each group). Representative images of xenograft nodules are indicated by yellow circles (left). Quantification results of nodules are also indicated (right). C Control or POSTN-expressing vector was transfected into SKOV3 cells containing stable luciferase expression plasmid and orthotopically injected into ovary capsules of the mice. The kinetics of abdominal metastases was monitored by BLI. D Histogram of quantitative BLI signals showed the abdominal or specific organ metastasis of SKOV3/POSTN-bearing mice comparing with control mice. E Representative BLI images showed the metastasis potential of SKOV-I6/SC or SKOV-I6/shPOSTN by BLI. F The quantitative data from E. *p < 0.05; ***p < 0.001

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