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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS

Fig. 7

SD prolongs the life-span of ALS (G93A) mice. A Pre-symptomatic supplementation of SD delayed disease onset in ALS mice (n = 10) compared to vehicle (saline) control (n = 10). B SD administration prolonged the life-span of ALS mice as shown by Kaplan–Meier probability of survival analysis. The statistics were calculated by Mantel–Cox test. C SD administration prevented loss of motor neurons in the ventral horn of spinal cord in G93A mice. Lumbar spinal cord tissue sections were stained with cresyl violet (Nissl staining). Scale bars: 20 μm. D SD administration improved the size of motor neurons. The number of cell counting: 40 cells/group. E SD administration restored a total number of motor neurons in the ventral horn of G93A. F SD administration improved the bodyweight of ALS mice (n = 10) compared to vehicle (saline)-treated ALS mice (n = 10) after 14 weeks. The statistics for body weight was calculated by Wilcoxon matched-pairs signed rank test. Significantly different at *p < 0.05 and **p < 0.01

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