Fig. 9

Summarized diagrams depicting the protective role of polyamine (spermidine) against LSD1-H3K4me2 pathway-dependent motor neuronal dysfunction in ALS. A In the ALS condition, elevation of LSD1 activity reduces the level of H3K4me2 and subsequently downregulates motor neuronal genes, leading to motor neuronal dysfunction. B SD therapy modulates the activity of LSD1 and the expression of epigenomes, ameliorating motor neuron function and neuropathology in ALS. BioRender software has been used to draw the above scheme