Fig. 7From: Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathymRNAs and associated putative eRNAs expressed at photoreceptor specific gene loci are downregulated in SCA7 homozygous mice. Graphs showing the RT-qPCR analysis of mRNA and associated putative eRNA levels expressed at photoreceptor gene loci in the retina of SCA7140Q/140Q homozygous mice and WT littermates at 12.5 weeks. All mRNAs and annotated putative eRNAs of photoreceptor genes show downregulation in SCA7 retina compared to WT. The non-deregulated Patl1 gene and associated non-deregulated non-coding RNA (based on RNA-seq) were used as control. The non-deregulated Hprt gene which has no associated lncRNA was used as negative, strand specific control. Data are normalized on Rplp0 mRNA expression level, expressed as mean ± SEM (n = 3–6) and analyzed using two-tailed Student’s t-test; *p < 0.05; **p < 0.01; ***p < 0.001Back to article page