Fig. 2
From: Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities
Key epigenetic mediators in the differentiation and exhaustion of CD8+ T cells. Upon antigen stimulation, naïve CD8+ T cells proliferate and differentiate into CD8+ effector T cells that produce anti-tumor effector cytokines. T cells may also adopt a memory phenotype following antigen clearance or an exhausted phenotype after repeated antigen stimulation. Various epigenetic modifiers are involved in the fate determination of naïve CD8+ T cells as they differentiate into effector, memory, or exhausted T (TEX) cells. This figure was created on BioRender.com